STIMULAN®

Uniquely engineered for the precision and control you demand every time

Bullet Mat and Introducer

Streamlined, flexible design that simplifies delivery of STIMULAN into hard-to-reach defects.

Our STIMULAN® distributor

Biocomposites has an exclusive agreement with LifeHealthcare to sell STIMULAN® products in Australia.

LifeHealthcare is one of Australia’s leading providers of medical device solutions with a team of complex orthopaedic experts that focus on infection, revision arthroplasty, oncology, limb deformity, paediatrics and biologics.

Visit LifeHealthcare

Perfect partner for managing dead space

STIMULAN is a truly absorbable calcium sulfate, specifically designed to complement your dead space management.1

  • Can be placed directly into bone voids and defects

Choosing an innovative void management device as part of your patient management strategy is key to:

  • Minimising avoidable complications
  • Improving outcomes
  • Reducing costs

Consistency is hard earned and uniquely achieved

STIMULAN is uniquely engineered through our DRy26™ recrystallization method.2 Each and every synthesis undergoes a 26 step process that starts with pharmaceutical grade precursors and takes over 6 weeks to reach maturity.

Properties that drive performance

STIMULAN is a pharmaceutical-grade calcium sulfate with a unique crystal structure that has tightly controlled properties.

  • Physiological pH
  • Controlled purity
  • No hydroxyapatite, insoluble impurities or PMMA debris
  • Hydrophilic

See the STIMULAN difference in your cases

  • Completely absorbs at an optimal rate1,3-8
  • Does not cause third body damage9,10
  • Does not prevent use in articulating surfaces9-10
  • Does not act as a nidus for infection3-8

Truly absorbable and totally synthetic calcium sulfate – absorbs at an optimal rate1,3-8

Leaves no nidus for infection.

Post-operative
1 month
11 weeks
6 months

Hydrophilic for fast, easy mixing

No soaking required

STIMULAN - mixes with liquid
Competitor calcium sulfate - repels liquid

No third body damage to articulating surfaces

Less scratching than competitor calcium sulfate

STIMULAN does not damage total knee replacements when trapped between the articulating surfaces of the implant

Microscope images (x6.5) of a cobalt chrome plate following damage simulation(360,000 cycles) with third body particles trapped between it and an articulating UHMWPE pin

STIMULAN
Competitor calcium sulfate
Control

Case-by-case flexibility

Every part of STIMULAN has been designed to provide simplicity, intra-operative flexibility and optimum results. A variety of formats are available, all convenient and fast to set.

STIMULAN® products
STIMULAN® Bullet Mat and Introducer

Innovative design that simplifies delivery into hard-to-reach defects.

  • Bullets have a groove down one side to reduce the risk of pressurizing the defect site
  • Bullets can be prepared in two diameters – 7mm and 9mm
STIMULAN® Rapid Cure

Rapid setting paste with individual bead kit.

  • Beads can be prepared in three sizes; 3, 4.8 and 6mm
  • Available in 5cc, 10cc and 20cc packs (bead volume 12cc, 25cc and 50cc)
  • Rapid setting in approx. 4 minutes
STIMULAN® Kit

Standard setting, fully injectable paste with individual bead kit.

  • Beads can be prepared in three sizes; 3, 4.8 and 6mm
  • Available in 5cc and 10cc packs (bead volume 10cc and 20cc)
  • Standard setting in approx. 8 minutes
How to prepare STIMULAN Rapid Cure
06:13
STIMULAN Bullet Mat and Introducer technique guide
04:19
Dr Webb case study - bilateral high energy femoral fractures
03:24
Frequently asked questions
How long does STIMULAN take to absorb?

STIMULAN is absorbed in approximately 30-90 days when used in accordance with the device labelling. Contributing factors include the vascularity of the surgical site, quantity used and patient health.

Does STIMULAN damage articulating surfaces on joint prosthesis?

Biomechanical testing (Pin on Plate) indicates that STIMULAN does not significantly scratch implant grade cobalt chrome and does not lead to increased wear of high-density polyethylene components, when compared to a control with no STIMULAN present.

References and regulatory statements

1. Biocomposites, STIMULAN Instructions for Use (AU). 2. Biocomposites, Data on file, Mr. Sharma. 3. Biocomposites, Data on file, Dr. Schlatterer. 4. Biocomposites, Data on file, Dr. Webb. 5. Cooper, J.J., Method of producing surgical grade calcium sulphate; Patent. 1999. 6. Somasundaram, K., Huber, C.P., Babu, V., et al., Proximal humeral fractures: the role of calcium sulphate augmentation and extended deltoid splitting approach in internal fixation using locking plates. Injury, 2013. 44(4): 481-7. 7. Lei D., Zhanzhong, M., Huaikuo, Y., et al., Treatment of Distal Radius Bone Defects with Injectable Calcium Sulphate Cement. In: Bone Grafting, A., Zorzi, Editor. 2012, InTech. p. 125-134. 8. Lei, D., Jing, L., Yang-yong, S., Calcium sulfate versus calcium phosphate in treating traumatic fractures. Journal of Clinical Rehabilitative Tissue Engineering Research, 2008. 12. 9. Lei, D., Ma, Z., Jing, X., Treatment of bone defect with injectable calcium sulfate powder in distal fractures of radius. Chinese Journal of Bone Tumor and Bone Disease, 2007. 10. Aiken, S.S., Cooper, J.J., Zhou, S., Osseointegration of a calcium sulphate bone substitute in a large animal model, in The 5th International Congress of Chinese Orthopaedic Association. 2010: Chengdu, China. 11. Lazarou, S.A., Contodimos, G.B., Gkegkes, I.D., Correction of alveolar cleft with calciumbased bone substitutes. J Craniofac Surg, 2011. 22(3): 854-7. 12. Analysis of the Wear Effect 3rd Body Particulate (Bone Cement) has on UHMWPE, Accutek Testing Laboratory, Fairfield OH, K13107732-1, 2014. 13. Cowie, R.M., et al., The influence of a calcium sulphate bone void filler on the third-body damage and polyethylene wear of total knee arthroplasty. Bone Joint Res, 2019. 8(2): p. 65-72.

For indications, contraindications, warnings and precautions see Instructions for Use. Concurrent use of locally administered antibiotics may affect setting time.

©2022, Biocomposites, STIMULAN, Bringing Calcium to Life, Power to Transform and DRy26 are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710, EP 3058899 B1, US 10390954, US 10,588,748, CN ZL201610089710.5

Patents pending: GB1502655.2, GB1704688.9, EP 18275044.8, US 15/933936, CN 108619579A

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